Human Immunodeficiency Virus Protease Inhibitors Serve as Substrates for Multidrug Transporter Proteins MDR1 and MRP1 but Retain Antiviral Efficacy in Cell Lines Expressing These Transporters

The human immunodeficiency virus type 1 (HIV-1) protease inhibitors (PIs)—saquinavir, ritonavir, nelfinavir, and indinavir—interact with the ABC-type multidrug transporter proteins MDR1 and MRP1 in CEM T-lymphocytic cell lines. Calcein fluorescence was significantly enhanced in MDR1(+) CEM/VBL100 an...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Srinivas, Ranga V., Middlemas, David, Flynn, Pat, Fridland, Arnold
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1998
Assuntos:	Antiviral Agents
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC106016/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9835508/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.42.12.3157
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