Human Immunodeficiency Virus Protease Inhibitors Serve as Substrates for Multidrug Transporter Proteins MDR1 and MRP1 but Retain Antiviral Efficacy in Cell Lines Expressing These Transporters

The human immunodeficiency virus type 1 (HIV-1) protease inhibitors (PIs)—saquinavir, ritonavir, nelfinavir, and indinavir—interact with the ABC-type multidrug transporter proteins MDR1 and MRP1 in CEM T-lymphocytic cell lines. Calcein fluorescence was significantly enhanced in MDR1(+) CEM/VBL100 an...

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Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Srinivas, Ranga V., Middlemas, David, Flynn, Pat, Fridland, Arnold
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology 1998
Ämnen:
Antiviral Agents
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC106016/
https://ncbi.nlm.nih.gov/pubmed/9835508
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