Antifungal Efficacy, Safety, and Single-Dose Pharmacokinetics of LY303366, a Novel Echinocandin B, in Experimental Pulmonary Aspergillosis in Persistently Neutropenic Rabbits

LY303366 is a novel semisynthetic derivative of echinocandin B and a potent inhibitor of fungal (1,3)-β-d-glucan synthase. The antifungal efficacy and safety of LY303366 were investigated in treatment and prophylaxis of primary pulmonary aspergillosis due to Aspergillus fumigatus in persistently neu...

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Main Authors: Petraitis, Vidmantas, Petraitiene, Ruta, Groll, Andreas H., Bell, Aaron, Callender, Diana P., Sein, Tin, Schaufele, Robert L., McMillian, Carl L., Bacher, John, Walsh, Thomas J.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 1998
Fag:
Experimental Therapeutics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC105963/
https://ncbi.nlm.nih.gov/pubmed/9797223
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