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Antifungal Efficacy, Safety, and Single-Dose Pharmacokinetics of LY303366, a Novel Echinocandin B, in Experimental Pulmonary Aspergillosis in Persistently Neutropenic Rabbits

LY303366 is a novel semisynthetic derivative of echinocandin B and a potent inhibitor of fungal (1,3)-β-d-glucan synthase. The antifungal efficacy and safety of LY303366 were investigated in treatment and prophylaxis of primary pulmonary aspergillosis due to Aspergillus fumigatus in persistently neu...

Celý popis

Uloženo v:
Vydáno v:Antimicrob Agents Chemother
Hlavní autoři: Petraitis, Vidmantas, Petraitiene, Ruta, Groll, Andreas H., Bell, Aaron, Callender, Diana P., Sein, Tin, Schaufele, Robert L., McMillian, Carl L., Bacher, John, Walsh, Thomas J.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology (ASM) 1998
Témata:
Experimental Therapeutics
On-line přístup:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC105963/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9797223/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.42.11.2898
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