The MODY1 gene HNF-4α regulates selected genes involved in insulin secretion

Mutations in the gene encoding hepatocyte nuclear factor-4α (HNF-4α) result in maturity-onset diabetes of the young (MODY). To determine the contribution of HNF-4α to the maintenance of glucose homeostasis by the β cell in vivo, we derived a conditional knockout of HNF-4α using the Cre-loxP system....

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Autores principales: Gupta, Rana K., Vatamaniuk, Marko Z., Lee, Catherine S., Flaschen, Reed C., Fulmer, James T., Matschinsky, Franz M., Duncan, Stephen A., Kaestner, Klaus H.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2005
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1059446/
https://ncbi.nlm.nih.gov/pubmed/15761495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200522365
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