A Ser315Thr Substitution in KatG Is Predominant in Genetically Heterogeneous Multidrug-Resistant Mycobacterium tuberculosis Isolates Originating from the St. Petersburg Area in Russia

Parts of katG and rpoB from 27 Russian Mycobacterium tuberculosis isolates were sequenced to detect mutations causing resistance to isoniazid (INH) and rifampin (RMP), respectively. All 24 INH-resistant isolates had a mutated katG, and 22 of them (91.7%) carried a mutation coding for a Ser315Thr shi...

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Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	Marttila, Harri J., Soini, Hanna, Eerola, Erkki, Vyshnevskaya, Elena, Vyshnevskiy, Boris I., Otten, Tatjana F., Vasilyef, Alexandr V., Viljanen, Matti K.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1998
Soggetti:	Mechanisms of Resistance
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC105851/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9736581/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.42.9.2443
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