A Ser315Thr Substitution in KatG Is Predominant in Genetically Heterogeneous Multidrug-Resistant Mycobacterium tuberculosis Isolates Originating from the St. Petersburg Area in Russia

Parts of katG and rpoB from 27 Russian Mycobacterium tuberculosis isolates were sequenced to detect mutations causing resistance to isoniazid (INH) and rifampin (RMP), respectively. All 24 INH-resistant isolates had a mutated katG, and 22 of them (91.7%) carried a mutation coding for a Ser315Thr shi...

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Veröffentlicht in:	Antimicrob Agents Chemother
Hauptverfasser:	Marttila, Harri J., Soini, Hanna, Eerola, Erkki, Vyshnevskaya, Elena, Vyshnevskiy, Boris I., Otten, Tatjana F., Vasilyef, Alexandr V., Viljanen, Matti K.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1998
Schlagworte:	Mechanisms of Resistance
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC105851/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9736581/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.42.9.2443
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