Dosing of Aminoglycosides To Rapidly Attain Pharmacodynamic Goals and Hasten Therapeutic Response by Using Individualized Pharmacokinetic Monitoring of Patients with Pneumonia Caused by Gram-Negative Organisms

Achieving a peak aminoglycoside concentration (C(max))/MIC of ≥10 within 48 h of initiation of therapy for pneumonia caused by gram-negative organisms results in a 90% probability of therapeutic response by day 7. Targeting an MIC of 1 μg/ml, empirical aminoglycoside loading doses of 348 (25th- to 7...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
Main Authors: Kashuba, A. D. M., Bertino, J. S., Nafziger, A. N.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Microbiology 1998
נושאים:
Pharmacology
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC105693/
https://ncbi.nlm.nih.gov/pubmed/9661031
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