Dosing of Aminoglycosides To Rapidly Attain Pharmacodynamic Goals and Hasten Therapeutic Response by Using Individualized Pharmacokinetic Monitoring of Patients with Pneumonia Caused by Gram-Negative Organisms
Achieving a peak aminoglycoside concentration (C(max))/MIC of ≥10 within 48 h of initiation of therapy for pneumonia caused by gram-negative organisms results in a 90% probability of therapeutic response by day 7. Targeting an MIC of 1 μg/ml, empirical aminoglycoside loading doses of 348 (25th- to 7...
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| Publicado no: | Antimicrob Agents Chemother |
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| Principais autores: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology (ASM)
1998
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC105693/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9661031/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.42.7.1842 |
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