Efficacy of NS-718, a Novel Lipid Nanosphere-Encapsulated Amphotericin B, against Cryptococcus neoformans

In vitro and in vivo efficacies of NS-718, a lipid nanosphere-encapsulated amphotericin B (AMPH-B), have been studied. Of the tested AMPH-B formulations, NS-718 had the lowest MIC for Cryptococcus neoformans. In a murine model, low-dose therapy (0.8 mg/kg of body weight) with NS-718 showed higher ef...

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Bibliographische Detailangaben
Hauptverfasser: Hossain, Mohammad Ashraf, Maesaki, Shigefumi, Kakeya, Hiroshi, Noda, Tetsuhiro, Yanagihara, Katsunori, Sasaki, Eisuke, Hirakata, Yoichi, Tomono, Kazunori, Tashiro, Takayoshi, Kohno, Shigeru
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 1998
Schlagworte:
Experimental Therapeutics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC105673/
https://ncbi.nlm.nih.gov/pubmed/9661011
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