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Efficacy of NS-718, a Novel Lipid Nanosphere-Encapsulated Amphotericin B, against Cryptococcus neoformans

In vitro and in vivo efficacies of NS-718, a lipid nanosphere-encapsulated amphotericin B (AMPH-B), have been studied. Of the tested AMPH-B formulations, NS-718 had the lowest MIC for Cryptococcus neoformans. In a murine model, low-dose therapy (0.8 mg/kg of body weight) with NS-718 showed higher ef...

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Uloženo v:
Vydáno v:Antimicrob Agents Chemother
Hlavní autoři: Hossain, Mohammad Ashraf, Maesaki, Shigefumi, Kakeya, Hiroshi, Noda, Tetsuhiro, Yanagihara, Katsunori, Sasaki, Eisuke, Hirakata, Yoichi, Tomono, Kazunori, Tashiro, Takayoshi, Kohno, Shigeru
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology (ASM) 1998
Témata:
Experimental Therapeutics
On-line přístup:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC105673/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9661011/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.42.7.1722
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