Selection and Characterization of β-Lactam–β-Lactamase Inactivator-Resistant Mutants following PCR Mutagenesis of the TEM-1 β-Lactamase Gene

Mechanism-based inactivators of β-lactamases are used to overcome the resistance of clinical pathogens to β-lactam antibiotics. This strategy can itself be overcome by mutations of the β-lactamase that compromise the effectiveness of their inactivation. We used PCR mutagenesis of the TEM-1 β-lactama...

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Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	Vakulenko, Sergei B., Geryk, Bruce, Kotra, Lakshmi P., Mobashery, Shahriar, Lerner, Stephen A.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1998
Soggetti:	Mechanisms of Resistance
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC105642/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9660980/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.42.7.1542
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