Quantitative Structure-Activity Relationship Studies of a Series of Sulfa Drugs as Inhibitors of Pneumocystis carinii Dihydropteroate Synthetase

Sulfone and sulfanilamide sulfa drugs have been shown to inhibit dihydropteroate synthetase (DHPS) isolated from Pneumocystis carinii. In order to develop a pharmacophoric model for this inhibition, quantitative structure-activity relationships (QSAR) for sulfa drugs active against DHPS have been st...

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Bibliografiske detaljer

Udgivet i:	Antimicrob Agents Chemother
Principais autores:	Johnson, Theresa, Khan, Ikhlas A., Avery, Mitchell A., Grant, Juliana, Meshnick, Steven R.
Format:	Artigo
Sprog:	Inglês
Udgivet:	American Society for Microbiology (ASM) 1998
Fag:	Mechanisms of Action: Physiological Effects
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC105621/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9624493/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.42.6.1454
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