Alterations in PBP 1A Essential for High-Level Penicillin Resistance in Streptococcus pneumoniae

High-level penicillin resistance in pneumococci is due to alterations in penicillin-binding proteins (PBPs) 2X, 2B, and 1A. We have sequenced the penicillin-binding domain of PBP 1A from penicillin-resistant South African pneumococcal isolates and have identified amino acid substitutions which are c...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Smith, Anthony M., Klugman, Keith P.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1998
Assuntos:	Mechanisms of Resistance
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC105597/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9624469/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.42.6.1329
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