Ribosomes from an Oxazolidinone-Resistant Mutant Confer Resistance to Eperezolid in a Staphylococcus aureus Cell-Free Transcription-Translation Assay

Oxazolidinone-resistant mutants of Staphylococcus aureus, isolated with a spiral plating technique, had a 16-fold higher MIC (2 versus 32 μg/ml) of eperezolid when compared to the parental sensitive strain. Eperezolid inhibited in vitro protein translation with 50% inhibitory concentrations of 30 μM...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Murray, Robert W., Schaadt, Ronda D., Zurenko, Gary E., Marotti, Keith R.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1998
Assuntos:	Mechanisms of Resistance
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC105576/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9559817/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.42.4.947
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