Duration and Clinical Relevance of Postantibiotic Effect in Relation to the Dosing Interval

The influence of half-life on the postantibiotic effect (PAE) of tobramycin against Pseudomonas aeruginosa and Staphylococcus aureus was investigated during one dosing interval. Tobramycin half-lives of 0.5 to 2.5 h were simulated in an in vitro model, and the PAE was determined by an enzymatic inac...

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Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	den Hollander, Jan G., Fuursted, Kurt, Verbrugh, Henri A., Mouton, Johan W.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1998
Soggetti:	Pharmacology
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC105536/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9559777/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.42.4.749
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