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Duration and Clinical Relevance of Postantibiotic Effect in Relation to the Dosing Interval

The influence of half-life on the postantibiotic effect (PAE) of tobramycin against Pseudomonas aeruginosa and Staphylococcus aureus was investigated during one dosing interval. Tobramycin half-lives of 0.5 to 2.5 h were simulated in an in vitro model, and the PAE was determined by an enzymatic inac...

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Autors principals: den Hollander, Jan G., Fuursted, Kurt, Verbrugh, Henri A., Mouton, Johan W.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 1998
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC105536/
https://ncbi.nlm.nih.gov/pubmed/9559777
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