Neurotoxicodynamics of the Interaction between Ciprofloxacin and Foscarnet in Mice

The potential for convulsions induced by the coadministration of ciprofloxacin (CPFX) and foscarnet (PFA) may be due not to a change in the distribution of CPFX to the brain but to a potential CPFX-induced inhibition of γ-aminobutyric acid (GABA)-GABA(A) receptor binding in the presence of PFA.

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Bibliographic Details
Main Authors: Matsuo, Hirotami, Ryu, Miwako, Nagata, Aya, Uchida, Takahiro, Kawakami, Jun-Ichi, Yamamoto, Koujirou, Iga, Tatsuji, Sawada, Yasufumi
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 1998
Subjects:
Pharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC105519/
https://ncbi.nlm.nih.gov/pubmed/9517953
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