Identification of GS 4104 as an Orally Bioavailable Prodrug of the Influenza Virus Neuraminidase Inhibitor GS 4071

GS 4071 is a potent carbocyclic transition-state analog inhibitor of influenza virus neuraminidase with activity against both influenza A and B viruses in vitro. GS 4116, the guanidino analog of GS 4071, is a 10-fold more potent inhibitor of influenza virus replication in tissue culture than GS 4071...

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izdano v:	Antimicrob Agents Chemother
Principais autores:	Li, Weixing, Escarpe, Paul A., Eisenberg, Eugene J., Cundy, Kenneth C., Sweet, Clive, Jakeman, Kenneth J., Merson, James, Lew, Willard, Williams, Matt, Zhang, Lijun, Kim, Choung U., Bischofberger, Norbert, Chen, Ming S., Mendel, Dirk B.
Format:	Artigo
Jezik:	Inglês
Izdano:	American Society for Microbiology (ASM) 1998
Teme:	Antiviral Agents
Online dostop:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC105512/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9517946/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.42.3.647
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