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The Lantibiotic Mersacidin Inhibits Peptidoglycan Synthesis by Targeting Lipid II

The lantibiotic mersacidin exerts its bactericidal action by inhibition of peptidoglycan biosynthesis. It interferes with the membrane-associated transglycosylation reaction; during this step the ultimate monomeric peptidoglycan precursor, undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)-GlcNAc (li...

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Detalhes bibliográficos
Main Authors: Brötz, Heike, Bierbaum, Gabriele, Leopold, Klaus, Reynolds, Peter E., Sahl, Hans-Georg
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 1998
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC105472/
https://ncbi.nlm.nih.gov/pubmed/9449277
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