Group D Adenoviruses Infect Primary Central Nervous System Cells More Efficiently than Those from Group C

Group C adenovirus-mediated gene transfer to central nervous system cells is inefficient. We found that wild-type group D viruses, or recombinant adenovirus type 2 (Ad2) (group C) modified to contain Ad17 (group D) fiber, were more efficient in infecting primary cultures of neurons. Together with st...

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Autores principales: Chillon, Miguel, Bosch, Assumpció, Zabner, Joseph, Law, Lane, Armentano, Donna, Welsh, Michael J., Davidson, Beverly L.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 1999
Materias:
Gene Therapy
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC104501/
https://ncbi.nlm.nih.gov/pubmed/9971839
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