Nef-Induced CD4 and Major Histocompatibility Complex Class I (MHC-I) Down-Regulation Are Governed by Distinct Determinants: N-Terminal Alpha Helix and Proline Repeat of Nef Selectively Regulate MHC-I Trafficking

The Nef protein of primate lentiviruses triggers the accelerated endocytosis of CD4 and of class I major histocompatibility complex (MHC-I), thereby down-modulating the cell surface expression of these receptors. Nef acts as a connector between the CD4 cytoplasmic tail and intracellular sorting path...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Mangasarian, Aram, Piguet, Vincent, Wang, Jen-Kuei, Chen, Yen-Liang, Trono, Didier
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1999
Assuntos:	Virus-Cell Interactions
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC104438/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9971776/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.73.3.1964-1973.1999
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