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Nef-Induced CD4 and Major Histocompatibility Complex Class I (MHC-I) Down-Regulation Are Governed by Distinct Determinants: N-Terminal Alpha Helix and Proline Repeat of Nef Selectively Regulate MHC-I Trafficking

The Nef protein of primate lentiviruses triggers the accelerated endocytosis of CD4 and of class I major histocompatibility complex (MHC-I), thereby down-modulating the cell surface expression of these receptors. Nef acts as a connector between the CD4 cytoplasmic tail and intracellular sorting path...

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Udgivet i:J Virol
Principais autores: Mangasarian, Aram, Piguet, Vincent, Wang, Jen-Kuei, Chen, Yen-Liang, Trono, Didier
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 1999
Fag:
Virus-Cell Interactions
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC104438/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9971776/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.73.3.1964-1973.1999
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