Expression of the p56(lck) Y505F Mutation in CD45-Deficient Mice Rescues Thymocyte Development

Mice deficient in the transmembrane protein tyrosine phosphatase CD45 exhibit a block in thymocyte development. To determine whether the block in thymocyte development was due to the inability to dephosphorylate the inhibitory phosphorylation site (Y505) in p56(lck) (Lck), we generated CD45-deficien...

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Pubblicato in:	Mol Cell Biol
Autori principali:	Seavitt, John R., White, Lynn S., Murphy, Kenneth M., Loh, Dennis Y., Perlmutter, Roger M., Thomas, Matthew L.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Taylor & Francis 1999
Soggetti:	Cell Growth and Development
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC104379/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10330160/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.19.6.4200
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