Expression of the p56(lck) Y505F Mutation in CD45-Deficient Mice Rescues Thymocyte Development

Mice deficient in the transmembrane protein tyrosine phosphatase CD45 exhibit a block in thymocyte development. To determine whether the block in thymocyte development was due to the inability to dephosphorylate the inhibitory phosphorylation site (Y505) in p56(lck) (Lck), we generated CD45-deficien...

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Main Authors: Seavitt, John R., White, Lynn S., Murphy, Kenneth M., Loh, Dennis Y., Perlmutter, Roger M., Thomas, Matthew L.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 1999
Teme:
Cell Growth and Development
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC104379/
https://ncbi.nlm.nih.gov/pubmed/10330160
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