Rapamycin Antifungal Action Is Mediated via Conserved Complexes with FKBP12 and TOR Kinase Homologs in Cryptococcus neoformans

Cryptococcus neoformans is a fungal pathogen that causes meningitis in patients immunocompromised by AIDS, chemotherapy, organ transplantation, or high-dose steroids. Current antifungal drug therapies are limited and suffer from toxic side effects and drug resistance. Here, we defined the targets an...

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Bibliografische Detailangaben

Veröffentlicht in:	Mol Cell Biol
Hauptverfasser:	Cruz, M. Cristina, Cavallo, Lora M., Görlach, Jenifer M., Cox, Gary, Perfect, John R., Cardenas, Maria E., Heitman, Joseph
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Taylor & Francis 1999
Schlagworte:	Cell Growth and Development
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC104369/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10330150/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.19.6.4101
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