Rapamycin Antifungal Action Is Mediated via Conserved Complexes with FKBP12 and TOR Kinase Homologs in Cryptococcus neoformans

Cryptococcus neoformans is a fungal pathogen that causes meningitis in patients immunocompromised by AIDS, chemotherapy, organ transplantation, or high-dose steroids. Current antifungal drug therapies are limited and suffer from toxic side effects and drug resistance. Here, we defined the targets an...

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Hlavní autoři: Cruz, M. Cristina, Cavallo, Lora M., Görlach, Jenifer M., Cox, Gary, Perfect, John R., Cardenas, Maria E., Heitman, Joseph
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 1999
Témata:
Cell Growth and Development
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC104369/
https://ncbi.nlm.nih.gov/pubmed/10330150
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