Improved Production of Gutted Adenovirus in Cells Expressing Adenovirus Preterminal Protein and DNA Polymerase

Production of gutted, or helper-dependent, adenovirus vectors by current methods is inefficient. Typically, a plasmid form of the gutted genome is transfected with helper viral DNA into 293 cells; the resulting lysate is serially passaged to increase the titer of gutted virions. Inefficient producti...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Hartigan-O’Connor, Dennis, Amalfitano, Andrea, Chamberlain, Jeffrey S.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1999
Assuntos:	Gene Therapy
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC104313/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10438876/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.73.9.7835-7841.1999
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