Targeted Recombination Demonstrates that the Spike Gene of Transmissible Gastroenteritis Coronavirus Is a Determinant of Its Enteric Tropism and Virulence

Targeted recombination within the S (spike) gene of transmissible gastroenteritis coronavirus (TGEV) was promoted by passage of helper respiratory virus isolates in cells transfected with a TGEV-derived defective minigenome carrying the S gene from an enteric isolate. The minigenome was efficiently...

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Detalles Bibliográficos

Publicado en:	J Virol
Autores principales:	Sánchez, Carlos M., Izeta, Ander, Sánchez-Morgado, Jose M., Alonso, Sara, Sola, Isabel, Balasch, Mónica, Plana-Durán, Juan, Enjuanes, Luis
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	American Society for Microbiology (ASM) 1999
Materias:	Pathogenesis and Immunity
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC104288/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10438851/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.73.9.7607-7618.1999
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