Targeted Recombination Demonstrates that the Spike Gene of Transmissible Gastroenteritis Coronavirus Is a Determinant of Its Enteric Tropism and Virulence

Targeted recombination within the S (spike) gene of transmissible gastroenteritis coronavirus (TGEV) was promoted by passage of helper respiratory virus isolates in cells transfected with a TGEV-derived defective minigenome carrying the S gene from an enteric isolate. The minigenome was efficiently...

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Bibliografische gegevens
Hoofdauteurs: Sánchez, Carlos M., Izeta, Ander, Sánchez-Morgado, Jose M., Alonso, Sara, Sola, Isabel, Balasch, Mónica, Plana-Durán, Juan, Enjuanes, Luis
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Microbiology (ASM) 1999
Onderwerpen:
Pathogenesis and Immunity
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC104288/
https://ncbi.nlm.nih.gov/pubmed/10438851
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