Recombinant Respiratory Syncytial Virus Bearing a Deletion of either the NS2 or SH Gene Is Attenuated in Chimpanzees

The NS2 and SH genes of respiratory syncytial virus (RSV) have been separately deleted from a recombinant wild-type RSV strain, A2 (M. N. Teng and P. L. Collins, J. Virol. 73:466–473, 1998; A. Bukreyev et al., J. Virol. 71:8973–8982, 1997; and this study). The resulting viruses, designated rA2ΔNS2 a...

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Hauptverfasser: Whitehead, Stephen S., Bukreyev, Alexander, Teng, Michael N., Firestone, Cai-Yen, St. Claire, Marisa, Elkins, William R., Collins, Peter L., Murphy, Brian R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 1999
Schlagworte:
Pathogenesis and Immunity
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC104109/
https://ncbi.nlm.nih.gov/pubmed/10074199
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