Woodchuck Hepatitis Virus Posttranscriptional Regulatory Element Enhances Expression of Transgenes Delivered by Retroviral Vectors

The expression of genes delivered by retroviral vectors is often inefficient, a potential obstacle for their widespread use in human gene therapy. Here, we explored the possibility that the posttranscriptional regulatory element of woodchuck hepatitis virus (WPRE) might help resolve this problem. In...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Zufferey, Romain, Donello, John E., Trono, Didier, Hope, Thomas J.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1999
Assuntos:	Gene Therapy
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC104046/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10074136/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.73.4.2886-2892.1999
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