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A Second-Site Mutation That Restores Replication of a Tat-Defective Human Immunodeficiency Virus

We previously constructed a large set of mutants of the human immunodeficiency virus type 1 (HIV-1) regulatory protein Tat with conservative amino acid substitutions in the activation domain. These Tat variants were analyzed in the context of the infectious virus, and several mutants were found to b...

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Detalles Bibliográficos
Main Authors: Verhoef, Koen, Berkhout, Ben
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 1999
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC104035/
https://ncbi.nlm.nih.gov/pubmed/10074125
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