Opposing Effects of Human Immunodeficiency Virus Type 1 Matrix Mutations Support a Myristyl Switch Model of Gag Membrane Targeting

Targeting of the human immunodeficiency virus type 1 (HIV-1) Gag precursor Pr55(gag) to the plasma membrane, the site of virus assembly, is primarily mediated by the N-terminal matrix (MA) domain. N-myristylation of MA is essential for the stable association of Pr55(gag) with membranes and for virus...

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Detalles Bibliográficos

Publicado en:	J Virol
Principais autores:	Paillart, Jean-Christophe, Göttlinger, Heinrich G.
Formato:	Artigo
Idioma:	Inglês
Publicado:	American Society for Microbiology (ASM) 1999
Assuntos:	Structure and Assembly
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC104015/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10074105/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.73.4.2604-2612.1999
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