Perforin Is Essential for Control of Ectromelia Virus but Not Related Poxviruses in Mice

Lack of perforin renders the relatively resistant mouse strain C57BL/6 highly susceptible to the natural mouse pathogen ectromelia virus, a cytopathic orthopoxvirus. This is indicated by increased mortality, elevated virus titers and pathology in liver and spleen, and increased levels of liver enzym...

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Bibliografische Detailangaben

Veröffentlicht in:	J Virol
Hauptverfasser:	Müllbacher, Arno, Hla, Ron Tha, Museteanu, Crisan, Simon, Markus M.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1999
Schlagworte:	Pathogenesis and Immunity
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC103996/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9882377/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.73.2.1665-1667.1999
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