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Selection of Functional Variants of the NS3-NS4A Protease of Hepatitis C Virus by Using Chimeric Sindbis Viruses

The NS3-NS4A serine protease of hepatitis C virus (HCV) mediates four specific cleavages of the viral polyprotein and its activity is considered essential for the biogenesis of the HCV replication machinery. Despite extensive biochemical and structural characterization, the analysis of natural varia...

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Bibliografiset tiedot
Päätekijät: Filocamo, Gessica, Pacini, Laura, Nardi, Chiara, Bartholomew, Linda, Scaturro, Maria, Delmastro, Paola, Tramontano, Anna, De Francesco, Raffaele, Migliaccio, Giovanni
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Microbiology 1999
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Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC103862/
https://ncbi.nlm.nih.gov/pubmed/9847361
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