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Congenital thiopurine methyltransferase deficiency and 6-mercaptopurine toxicity during treatment for acute lymphoblastic leukaemia.

Two children with acute lymphoblastic leukaemia (ALL) taking daily 6-mercaptopurine as part of a national UK therapeutic trial repeatedly developed profound myelosuppression on 25% of the standard protocol dose. Both were found to have undetectable intracellular activity of thiopurine methyltransfer...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Lennard, L, Gibson, B E, Nicole, T, Lilleyman, J S
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1993
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1029622/
https://ncbi.nlm.nih.gov/pubmed/8257179
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