Interruption of the fragile X syndrome expanded sequence d(CGG)(n) by interspersed d(AGG) trinucleotides diminishes the formation and stability of d(CGG)(n) tetrahelical structures
Fragile X syndrome is caused by expansion of a d(CGG) trinucleotide repeat sequence in the 5′ untranslated region of the first exon of the FMR1 gene. Repeat expansion is thought to be instigated by formation of d(CGG)(n) secondary structures. Stable FMR1 d(CGG)(n) runs in normal individuals consist...
Gardado en:
| Publicado en: | Nucleic Acids Res |
|---|---|
| Principais autores: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Oxford University Press
2000
|
| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC102797/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10710419/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/28.7.1535 |
| Tags: |
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!
|