The C-terminal conserved domain of DNA-PKcs, missing in the SCID mouse, is required for kinase activity
DNA-PKcs, the catalytic subunit of DNA-dependent protein kinase (DNA-PK), has a phosphoinositol 3-kinase (PI 3-K) domain close to its C-terminus. Cell lines derived from the SCID mouse have been utilised as a model DNA-PKcs-defective system. The SCID mutation results in truncation of DNA-Pkcs at the...
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| Izdano u: | Nucleic Acids Res |
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| Glavni autori: | , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Oxford University Press
2000
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC102783/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10710416/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/28.7.1506 |
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