The C-terminal conserved domain of DNA-PKcs, missing in the SCID mouse, is required for kinase activity

DNA-PKcs, the catalytic subunit of DNA-dependent protein kinase (DNA-PK), has a phosphoinositol 3-kinase (PI 3-K) domain close to its C-terminus. Cell lines derived from the SCID mouse have been utilised as a model DNA-PKcs-defective system. The SCID mutation results in truncation of DNA-Pkcs at the...

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Publicat a:	Nucleic Acids Res
Autors principals:	Beamish, H. J., Jessberger, R., Riballo, E., Priestley, A., Blunt, T., Kysela, B., Jeggo, P. A.
Format:	Artigo
Idioma:	Inglês
Publicat:	Oxford University Press 2000
Matèries:	Article
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC102783/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10710416/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/28.7.1506
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