Regulation of the RNA-dependent protein kinase by triple helix formation

The RNA-dependent protein kinase (PKR) is an interferon-induced, RNA-activated enzyme that phosphorylates the α-subunit of the translation initiation factor eIF-2, inhibiting its function. PKR is activated in vitro by binding to double-stranded RNA (dsRNA) molecules of ~30 bp or longer. Here we show...

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Veröffentlicht in:	Nucleic Acids Res
Hauptverfasser:	Vuyisich, Momchilo, Beal, Peter A.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Oxford University Press 2000
Schlagworte:	Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC102732/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10871369/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/28.12.2369
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