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Human γ-globin gene promoter element regulates human β-globin gene developmental specificity

The persistence of fetal hemoglobin in many patients with deletion type β thalassemias and the expression patterns of human globin genes in transgenic mice suggest that γ- to β-globin gene switching results primarily from competition of γ- and β-globin genes for interaction with the β-globin locus c...

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Pubblicato in:Nucleic Acids Res
Autori principali: Ryan, T. M., Sun, C.-W., Ren, Jinxiang, Townes, T. M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2000
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Accesso online:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC102642/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10908330/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/28.14.2736
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