Structures of m-iodo Hoechst–DNA complexes in crystals with reduced solvent content: implications for minor groove binder drug design

The DNA photosensitisers m-iodo Hoechst and m-iodo, p-methoxy Hoechst have been co-crystallised with the oligonucleotide d(CGCGAATTCGCG)(2) and their crystal structures determined. The crystals were then subjected to slow dehydration, which reduced their solvent contents from 40 (normal) to 30 (part...

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Pubblicato in:	Nucleic Acids Res
Autori principali:	Squire, Christopher J., Baker, L. J., Clark, George R., Martin, Roger F., White, Jonathan
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Oxford University Press 2000
Soggetti:	Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC102593/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10666470/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/28.5.1252
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