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Interstrand cross-linking by Adriamycin in nuclear and mitochondrial DNA of MCF-7 cells

Activation of Adriamycin by formaldehyde leads to the formation of drug–DNA adducts in vitro and these adducts stabilise the DNA to such a degree that they function as virtual interstrand cross-links. The formation of these virtual interstrand cross-links by Adriamycin was investigated in MCF-7 cell...

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Udgivet i:Nucleic Acids Res
Principais autores: Cullinane, Carleen, Cutts, Suzanne M., Panousis, Con, Phillips, Don R.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2000
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Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC102585/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10648796/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/28.4.1019
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