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Uridylate Addition and RNA Ligation Contribute to the Specificity of Kinetoplastid Insertion RNA Editing

RNA editing in Trypanosoma brucei inserts and deletes uridylates (U's) in mitochondrial pre-mRNAs under the direction of guide RNAs (gRNAs). We report here the development of a novel in vitro precleaved editing assay and its use to study the gRNA specificity of the U addition and RNA ligation s...

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Bibliografiske detaljer
Main Authors: Igo, Robert P., Palazzo, Setareh S., Burgess, Moffett L. K., Panigrahi, Aswini K., Stuart, Kenneth
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2000
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC102151/
https://ncbi.nlm.nih.gov/pubmed/11046141
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