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Uridylate Addition and RNA Ligation Contribute to the Specificity of Kinetoplastid Insertion RNA Editing

RNA editing in Trypanosoma brucei inserts and deletes uridylates (U's) in mitochondrial pre-mRNAs under the direction of guide RNAs (gRNAs). We report here the development of a novel in vitro precleaved editing assay and its use to study the gRNA specificity of the U addition and RNA ligation steps...

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Published in:Mol Cell Biol
Main Authors: Igo, Robert P., Palazzo, Setareh S., Burgess, Moffett L. K., Panigrahi, Aswini K., Stuart, Kenneth
Format: Artigo
Language:Inglês
Published: Taylor & Francis 2000
Subjects:
Gene Expression
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC102151/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11046141/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.20.22.8447-8457.2000
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