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CD28 and the Tyrosine Kinase Lck Stimulate Mitogen-Activated Protein Kinase Activity in T Cells via Inhibition of the Small G Protein Rap1

Proliferation of T cells via activation of the T-cell receptor (TCR) requires concurrent engagement of accessory costimulatory molecules to achieve full activation. The best-studied costimulatory molecule, CD28, achieves these effects, in part, by augmenting signals from the TCR to the mitogen-activ...

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書誌詳細
主要な著者: Carey, Kendall D., Dillon, Tara J., Schmitt, John M., Baird, Allison M., Holdorf, Amy D., Straus, David B., Shaw, Andrey S., Stork, Philip J. S.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Microbiology 2000
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC102148/
https://ncbi.nlm.nih.gov/pubmed/11046138
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