CD28 and the Tyrosine Kinase Lck Stimulate Mitogen-Activated Protein Kinase Activity in T Cells via Inhibition of the Small G Protein Rap1

Proliferation of T cells via activation of the T-cell receptor (TCR) requires concurrent engagement of accessory costimulatory molecules to achieve full activation. The best-studied costimulatory molecule, CD28, achieves these effects, in part, by augmenting signals from the TCR to the mitogen-activ...

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Auteurs principaux: Carey, Kendall D., Dillon, Tara J., Schmitt, John M., Baird, Allison M., Holdorf, Amy D., Straus, David B., Shaw, Andrey S., Stork, Philip J. S.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2000
Sujets:
Cell Growth and Development
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC102148/
https://ncbi.nlm.nih.gov/pubmed/11046138
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