Pathogenicity of Hantaan Virus in Newborn Mice: Genetic Reassortant Study Demonstrating that a Single Amino Acid Change in Glycoprotein G1 Is Related to Virulence

Two Hantaan virus strains, clone 1 (cl-1), which is virulent in newborn mice, and its attenuated mutant (mu11E10), were used to examine the pathogenesis of Hantaan virus infection in a mouse model and identify virus factors relating to virulence. After subcutaneous inoculation of newborn BALB/c mice...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Ebihara, Hideki, Yoshimatsu, Kumiko, Ogino, Michiko, Araki, Koichi, Ami, Yasushi, Kariwa, Hiroaki, Takashima, Ikuo, Li, Dexin, Arikawa, Jiro
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2000
Assuntos:	Pathogenesis and Immunity
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC102124/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10982372/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.74.19.9245-9255.2000
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