Pathogenicity of Hantaan Virus in Newborn Mice: Genetic Reassortant Study Demonstrating that a Single Amino Acid Change in Glycoprotein G1 Is Related to Virulence

Two Hantaan virus strains, clone 1 (cl-1), which is virulent in newborn mice, and its attenuated mutant (mu11E10), were used to examine the pathogenesis of Hantaan virus infection in a mouse model and identify virus factors relating to virulence. After subcutaneous inoculation of newborn BALB/c mice...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Ebihara, Hideki, Yoshimatsu, Kumiko, Ogino, Michiko, Araki, Koichi, Ami, Yasushi, Kariwa, Hiroaki, Takashima, Ikuo, Li, Dexin, Arikawa, Jiro
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: American Society for Microbiology 2000
Θέματα:
Pathogenesis and Immunity
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC102124/
https://ncbi.nlm.nih.gov/pubmed/10982372
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