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Template/Primer Requirements and Single Nucleotide Incorporation by Hepatitis C Virus Nonstructural Protein 5B Polymerase

Nonstructural protein 5B (NS5B) of hepatitis C virus (HCV) possesses an RNA-dependent RNA polymerase activity responsible for viral genome RNA replication. Despite several reports on the characterization of this essential viral enzyme, little is known about the reaction pathway of NS5B-catalyzed nuc...

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Bibliografiske detaljer
Main Authors: Zhong, Weidong, Ferrari, Eric, Lesburg, Charles A., Maag, David, Ghosh, Saikat Kumar B., Cameron, Craig E., Lau, Johnson Y. N., Hong, Zhi
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2000
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC102112/
https://ncbi.nlm.nih.gov/pubmed/10982360
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